Clinical Study on the Effectiveness of Nishothamadi Ghanavati and Bruhat Danatapala Taila in the Management of Ekakushta (Psoriasis)

Yadu Narayanan Mooss ET, Girish KJ, Rich Singh


Background:Ekakushta is a Vatakapha predominent Tridoshaja skin disorder. Its features have close relationship with Psoriasis. Psoriasis is a chronic skin disorder of autoimmune origin affecting papulo-squamous cells. It is universal in occurrence and the incidence rate is 1-3% of the population worldwide. Asthavaidya practitioners of Kerala have been using a combination of Nishothamadi Kashaya and Bruhat Danatapala Taila in the management of Ekakushta since many years. Nishothamadi Kashaya is explained in classics as Kushtahara Kashaya. Tablet form of the same is selected for the ease of administration. Bruhat Dantapala Taila is an Anubhoota Yoga having Strikutaja as main ingredient. Clinical efficacy of this combination is not yet evaluated on a statistical basis. Hence this study was undertaken to evaluate its effectiveness in the management of Ekakushta (Psoriasis).

Methods: Among the 32 registered patients 30 of them completed the course of treatment and were administered with Nishothamadi Ghanavati orally six grams daily in divided doses after food and Bruhat Dantapala Taila for local application once daily for a period of thirty days. For statistical analysis subjective parameters were assessed by Wilcoxon signed rank and Cochran’s Q test. PASI scale was used as the assessment criteria. Repeated measures anova test was used for statistical analysis of PASI scale.

Results: There were statistically significant improvements in the signs and symptoms of Ekakustha except for Aswedana (Anhydrosis) (p<0.05).

Conclusion: This combination is found to be effective in the management of Ekakushta (Psoriasis) without any adverse drug reactions.

Keywords:Ayurveda, Traditional medicine,Ekakustha, Psoriasis, Nishothamadi Ghanavati, Bruhat Dantapala Taila, PASI scale


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